I had covid 4 months ago and came through it fairly easily - but the vaccine almost killed me. "Aside from COVID-19, I've never seen anything else cause markedly elevated factor V, and I've been doing this for 25 years," study co-author Dr. Elizabeth Van Cott said in a hospital news release. However, there is no a priori reason to believe that replication-deficient vaccines should be unsafe in this setting. What is an Emergency Use Authorization (EUA)? At least 2 months after 3rd dose or last booster, Moderna The Janssen Biotech vaccine contains a type of a human adenovirus. Up to Date: 2 weeks after 3rd primary dose; there is not a recommendation for an updated Pfizer-BioNTech booster for this age group. Its been suggested some form of immune activation, similar to that seen in HIT, might be the cause of what is happening in some vaccinated people. The safety, effectiveness, and benefit of the third primary dose in people who are moderately or severely immunocompromised continues to be evaluated. I also have heart disease and 1 stent in the L.A.D. We offer diagnostic and treatment options for common and complex medical conditions. The study results are published online in the American Journal of Hematology. Because of this, comparisons have been drawn with the contraceptive pill, which carries a greater relative risk of clots. SOUNDS TO ME LIKE THEY DON'T WANT THIS INFORMATION TO GET OUT. Okay, so that was what I had found about the rates of thrombosis in COVID patients - that there was a very high correlation in patients who died of COVID (71.4% in that first study), and that other numbers of all patients was somewhere between 7.9% and 25% depending on what subpopulation we were looking at. The vaccine does not contain a preservative. Their findings are: - Incidence of CVT after COVID diagnosis was 42.8 per million, including 35.3 per million first diagnosis. Following precautions such as infusing with a factor replacement product prior to or right after the vaccination and applying pressure for 10 minutes after the vaccination should be considered. More information on prescribing Comirnaty can be found at https://www.fda.gov/vaccines-blood-biologics/comirnaty. Your hematologist may advise you as to whether and when your platelet count should be checked after the first and/or second vaccination in addition to the baseline value. The vaccination is administered intra-muscularly but the smallest gauge needle should be used (25-27 gauge), if possible. The vaccine contains a recombinant, replication-incompetent human adenovirus serotype 26 (Ad26) vector, encoding the SARS-CoV-2 viral spike (S) glycoprotein, stabilized in its pre-fusion form. Have any of the vaccines been approved by the FDA? I spent five days in an ICU on high flow oxygen after failing to respond to nasal cannula, a non rebreather mask, or BIPAP., then another day and a half in a telemetry bed. The mRNA is used by the body to make a mimic of one of the proteins in the virus that causes COVID-19. Copyright 2007-2023. I was just getting ready to get my shot until I read that. Different COVID-19 vaccinations have varying schedules for booster shots. I would encourage anyone to spend some time on these sites, in addition to taking advantage of the use of Google Scholar to be able to see actual studies that have been published, if reading the publications that are meant for patients like us are not enough. 1. The most commonly reported side effects, which typically lasted several days, were pain at the injection site, tiredness, headache, muscle pain, chills, joint pain, swollen lymph nodes in the same arm as the injection, nausea and vomiting, and fever. Adapted from a Mass General news release. Pfizer-BioNTech or Moderna If blood clots occur when they shouldnt, this can be fatal. I have been on coumadin since 2007 and have a INR between 2-3. WebDTC (Direct-To-Consumer) Genetic Testing for Factor V Leiden. If you have a question about your specific situation, be sure to discuss it with your hematologist. I was diagnosed with parsonage Turner Syndrome after receiving a hep a vaccine in 2019. Is it safe for people with low platelets or ITP, or platelet function disorders to receive the COVID vaccine? At least 2 months after 3rd dose or last booster, Novavax People who are moderately or severely immunocompromised who have low or no protection after two doses of mRNA vaccines may have an improved immune response after a third primary dose of the same vaccine. How do I talk to my kids about the COVID-19 vaccine? Factor products that use PEG to extend the half-life of the factor product or any factor products are not a reason to not take a vaccine unless you have had a reaction to PEG. WebBOSTON Patients hospitalized with severe COVID-19 infections who have high levels of the blood clotting protein factor V are at elevated risk for serious injury from blood clots 1. Research studies are currently underway to evaluate the safety, tolerability, and immunogenicity of the both the Pfizer-BioNTech and Moderna COVID-19 vaccines in children 6 months to 11 years of age. If you have a bleeding disorder, there are no contraindications to being vaccinated with any of the three vaccines now available via EUA status for intramuscular administration. Staying up to date: If you have completed your primary seriesbut are not yet eligible for a boosteryou are also considered up to date. So far, reactions reported after the third primary dose of an mRNA COVID-19 vaccine are similar to those of the two-dose primary series. Just a sore arm for 2 days, similar to the flu vaccine, and I felt cold for a few days. At least 4 weeks after 2nd dose. About 5% of people categorised as white have this mutation, though it is much less common in other ethnic groups. Symptoms were similar to getting the Flu Shot. Importantly, the MGH investigators note that factor V elevation in COVID-19 could cause misdiagnosis of some patients, because under normal circumstances factor V levels are low in the presence of liver dysfunction or DIC. The researchers found that factor V levels were significantly elevated among patients with COVID-19 compared with controls, and they found the association between high factor V activity and COVID-19 was the strongest among all clinical parameters studied. Lancaster University provides funding as a founding partner of The Conversation UK. Meanwhile, I continue to isolate as much as possible, mask when I can't avoid indoor contact with others, in addition to being vaccinated, to keep myself safe. Since factor V Leiden is a risk for developing blood clots in the leg or lungs, the first indication that you have the disorder may be the development of an abnormal blood clot. Are you taking any medications with one of the following ingredientsone of those ingredients being a PEG? [CDATA[> Adenovirus is NOT used in hemophilia or any form of gene therapy and therefore is not a concern for our community including those who are considering receiving gene therapy in the future. Pfizer-BioNTech Both types of vaccines only introduce the gene for a single protein from the virus that causes COVID-19 the spike protein. I have had a massive dvt previously (thigh to calf) and have recurrent thrombophlebitis.. For people who are immunocompromised, the third primary dose is the final dose of the primary series of an mRNA COVID-19 vaccine. UPDATED BOOSTER, A Novavax booster is available in limited situations They studied the levels of these clotting factors and other parameters in a group of 102 consecutive patients with COVID-19 and compared the results with those of current critically ill patients without COVID-19, as well as against historical controls. Patients that are unsure about getting the vaccine should consult with their hematologist or another physician before proceeding. Ultrasound, Anticoagulant therapy, Antiphospholipid syndrome, Thrombophlebitis, Protein S deficiency, Carotid artery di sease, Fibromuscular dysplasia, Venous thrombosis, Factor V Leiden, Carotid artery dissection, Peripheral artery disease, Protein C deficiency, Renal artery stenosis, Pulmonary embolism, Thrombophilia, Aortic Four days later, this patient developed a saddle pulmonary embolism, a potentially fatal blood clot occurring at the junction of the left and right pulmonary arteries. This potential new condition has been called vaccine-induced prothrombotic immune thrombocytopenia (VIPIT). WebFactor V Leiden (FVL) is a change in your genes that affects one of the clotting factors in your blood and keeps your body's blood -clotting process from working right. People seeking additional information on can find a vaccine information sheet for Comirnaty at https://www.fda.gov/media/144414/download. All information these cookies collect is aggregated and therefore anonymous. 10. Below are some of the questions you may be asked, and an explanation as to why the people administering the vaccine might ask them. The General Hospital Corporation. But for some whove taken the vaccine, platelets appear to stick together in the venous sinuses of the brain, which causes a blockage that prevents blood draining out of the brain tissues. Patient is at higher risk from a COVID infection because of their factor V Leiden mutation and history of a deep vein blood clot. Now I am changing my mind. Fact check: COVID-19 vaccines won't cause a zombie apocalypse. https://pubmed.ncbi.nlm.nih.gov/32271988/). Following the vaccination, the area should be monitored for hematoma formation immediately for 10 minutes to reduce bleeding and swelling and by self-inspection 2-4 hours later at home to ensure that there is no delayed hematoma. I was the only ICU patient there not intubated at that time. I just read the post on the two individuals that developed blood clots after the Pfizer vaccine. But I do take aspirin daily. Medical Conditions. Are you sure you want to block this member? Patients with severe COVID-19 disease caused by the SARS-CoV-2 virus can develop blood clots in medical lines (intravenous lines, catheters, etc), and in arteries, lungs, and extremities, including the toes. These symptoms, as well as the mechanism underlying the formation of these clots, are similar to those from a different type of thrombosis, heparin induced thrombocytopenia (HIT), where specific antibodies bind to a molecule in the blood called heparin, causing platelets to become super sticky and clot. This was a paused based on 15 reports. I met with both my GP and my Hematologist last week about my concerns about the vaccine and both felt it was better to do than not, as I work in a Hotspot in Ontario, Canada. Would I be in a priority group to receive the vaccine with a bleeding disorder? Is it all right for me to drink alcoholic beverages at this age? Now the interesting question. COVID-19 Vaccines for People Who Are Moderately or Severely Immunocompromised, Centers for Disease Control and Prevention. Most commonly, side effects tend to be mild and usually only last a day or two. Am wondering if it's really any more risky than the other 2? Explore fellowships, residencies, internships and other educational opportunities. My drs felt that any vaccine was better than none, as the rate of blood clots if admitted to hospital with COVID goes up dramatically compared to the rate of blood clots linked to the vaccines - based on what I have read. I am also hetero factor V leiden. 4 weeks after 1st dose, Moderna It is amazing how we have to be our own doctors, researchers and advocates. My son may suffer from lasting consequences from it as his case is much worse than mine. //--> For more information about these cookies and the data Discomfort in the arm felt for 1-2 days after injection should not be alarming unless it worsens and is accompanied by swelling. Both the FDA and CDC have approved the Moderna COVID-19 vaccine for children ages 5 and younger, and the Pfizer-BioNTech COVID-19 vaccine for those ages 4 and under. Some vaccines must be administered using the accompanying needlesyringe combination, and so the use of an alternative needle may not be possible or desirable. I recovered fairly quickly but it was certainly painful, scary and if we both weren't active with strong hearts we might not have made it. The vaccine is also authorized to provide a third primary series dose at least one month following the second dose for individuals in this age group who have been determined to have certain kinds of immunocompromise. Now, there were some differences in the primary efficacy against all forms of COVID-19. In all, 33 percent of patients with factor V activity well above the reference range had either deep vein thrombosis or a pulmonary embolism, compared with only 13 percent of patients with lower levels. Mohammed Haneefa Nizamudeen/iStock/Getty Images Plus. They studied the levels of these clotting factors and other parameters in a group of 102 consecutive patients with COVID-19, and compared the results with those of current critically ill patients without COVID-19, and with historical controls. Is it safe for a person with a bleeding disorder to receive the COVID vaccine? (https://osf.io/a9jdq/?show=view). The data suggest that the three vaccines are probably effective against COVID-19 variants, however, the efficacy of the vaccines will need to be reexamined as new strains emerge. People with a history of infection who have ALSO gotten three doses of an mRNA vaccine have very high protection against future infection with all the variants known until now. The vaccine contains a nucleoside-modified messenger RNA encoding the viral spike (S) glycoprotein of SARS-CoV-2 formulated in lipid particles. Both the FDA and CDC have approved the Moderna COVID-19 vaccine for children ages 5 and younger, and the Pfizer-BioNTech COVID-19 vaccine for those ages When the Johnson & Johnson vaccine was temporarily paused, it was because of rare form of blood clot (thrombossis with thrombocytopenia syndrome), nearly all in people like me (women under 50). The study results are published online Aug. 24 in the American Journal of Hematology. The EUA allows the Janssen COVID-19 Vaccine to be distributed in the U.S. for use in individuals 18 years of age and older.to prevent COVID-19. People who are moderately or severely immunocompromised and who received COVID-19 vaccines not available in the United States should either complete or restart the recommended COVID-19 vaccine series, including a booster, in the United States. At Mass General, the brightest minds in medicine collaborate on behalf of our patients to bridge innovation science with state-of-the-art clinical medicine. Also wondering if our condition meets the provincial gov't "high risk conditions", Did your docs have an opinion on which vaccine given our condition? House Beautiful: Brentwood Bay dream house, Helen Chesnut's Garden Notes: The hunt for the elusive Champagne, Condo Smarts: 'Underused housing tax' may apply to guest suites. Discomfort at the injection site is to be expected. These cookies may also be used for advertising purposes by these third parties. Common side effects for children can include pain at the injection site, fatigue, headaches, muscle and joint pain, and fever. WebIn the human body, factor V is a protein that is necessary for proper blood clotting. WebThe factor V Leiden mutation itself doesnt have any specific treatment. In early March, President Biden announced that all Americans are supposed to be eligible for vaccinations by May 1. Other co-authors of the study include Bianca B. Christensen, MD, MPH; Tasos Gogakos, MD, PhD; Jensyn K. Cone Sullivan, MD; Gabriella G. Montgomery, BS; and John P. Barranco, BS, all of Mass General and Harvard Medical School. At this time Im very skeptical about receiving a COVID-19 vaccine because of my reaction to the hep a vaccine. As blood leaves the brain, it drains into a dedicated space that exists around it the cerebral venous sinuses prior to it being channelled into the major veins that drain out of the head and into the neck, back to the heart. https://onlinelibrary.wiley.com/doi/full/10.1111/jth.14768. The Centers for Disease Control and Prevention (CDC) and the FDA have safety monitoring systems in place to capture information about vaccination during pregnancy and will closely monitor reports. Any of the currently authorized COVID-19 vaccines can be offered to people who are pregnant or breastfeeding. At age 90+, you are entitled to do what you want, and that includes making health decisions that might not be the most ideal for overall health. Sure, I did my research quite a while ago, and when I went back to some of the sources I trust (especially National Blood Clot Alliance and World Thrombosis Day) I found even more useful information. Finally, its important to note that COVID-19 itself has been reported to lead to thrombocytopenia in up to 41% of positive patients, with the figure rising to up to 95% in those with severe disease. My 30 yr old son who is homozygous for Factor V also developed blood clots in both of his lungs 2 weeks after getting the Pfizer vaccine. I believe this was used of God and was providential. It was the most terrifying week of my life. Search for condition information or for a specific treatment program. 3. 3 weeks after 1st dose, Pfizer-BioNTech or Moderna I've had two significant clots in the my left leg over the past 11 years and now am on Eliquis for life. Invite them to speak with their pediatrician for additional information. The factor V Leiden mutation puts people at higher risk for developing blood clots. The vaccine also continues to be available under emergency use authorization (EUA), including for individuals 12 through 15 years of age and for the administration of a third dose in certain immunocompromised individuals. What is factor V Leiden thrombophilia? Let us help you navigate your in-person or virtual visit to Mass General. Readers may email questions to ToYourGoodHealth@med.cornell.edu, Sign in or register for your free account. People can stay up to datewith COVID-19 vaccination by completing a primary series and receiving the most recent booster dose recommended for them by CDC. There are two potential warnings. TheMGH Research Instituteconducts the largest hospital-based research program in the nation, with an annual research budget of more than $1 billion and comprises more than 8,500 researchers working across more than 30 institutes, centers and departments. I made an appointment to get the Pfizer, but now I'm hesitant. PRIMARY SERIES MASAC Document 221 Recommendations on Administration of Vaccines to Individuals with Bleeding Disorders. 2022 United Airlines New York City Half Marathon, The Red Thread: NHF's 75th Anniversary Celebration, Judith Graham Pool Postdoctoral Research Fellowship, HANDI - NHFs Information Resource Center, https://www.fda.gov/vaccines-blood-biologics/comirnaty, https://www.fda.gov/media/144414/download. Boosters are shots that enhance or restore protection against COVID-19, which may have decreased over time. As the virus mutates or changes, these changes may be in the Spike protein causing the vaccines to be less effective against these mutated strains of the virus. UPDATED BOOSTER What is the vaccine emergency use authorization (EUA) in the United States? Learn about the many ways you can get involved and support Mass General. ADDITIONAL DOSE Im looking for as much information as I can find on this subject. I have participated in reddit AMAs hosted by World Thrombosis Day, that were a good opportunity to ask questions and get answers directly from international hematology expersts.
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